Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial.
Identifieur interne : 001A69 ( Main/Exploration ); précédent : 001A68; suivant : 001A70Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial.
Auteurs : Andrea Wang-Gillam [États-Unis] ; Chung-Pin Li [Taïwan] ; György Bodoky [Hongrie] ; Andrew Dean [Australie] ; Yan-Shen Shan [Taïwan] ; Gayle Jameson [États-Unis] ; Teresa Macarulla [Espagne] ; Kyung-Hun Lee [Corée du Sud] ; David Cunningham [Royaume-Uni] ; Jean F. Blanc [France] ; Richard A. Hubner [Royaume-Uni] ; Chang-Fang Chiu [Taïwan] ; Gilberto Schwartsmann [Brésil] ; Jens T. Siveke [Allemagne] ; Fadi Braiteh [États-Unis] ; Victor Moyo [États-Unis] ; Bruce Belanger [États-Unis] ; Navreet Dhindsa [États-Unis] ; Eliel Bayever [États-Unis] ; Daniel D. Von Hoff [États-Unis] ; Li-Tzong Chen [Taïwan]Source :
- Lancet (London, England) [ 1474-547X ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Camptothécine (administration et posologie), Camptothécine (analogues et dérivés), Camptothécine (effets indésirables), Carcinome du canal pancréatique (mortalité), Carcinome du canal pancréatique (traitement médicamenteux), Diarrhée (), Désoxycytidine (administration et posologie), Désoxycytidine (analogues et dérivés), Désoxycytidine (effets indésirables), Estimation de Kaplan-Meier, Fatigue (), Femelle, Fluorouracil (administration et posologie), Fluorouracil (effets indésirables), Humains, Leucovorine (administration et posologie), Leucovorine (effets indésirables), Liposomes, Mâle, Métastase tumorale, Neutropénie (), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Résultat thérapeutique, Sujet âgé, Tumeurs du pancréas (mortalité), Tumeurs du pancréas (traitement médicamenteux), Vomissement ().
- MESH :
- administration et posologie : Camptothécine, Désoxycytidine, Fluorouracil, Leucovorine.
- analogues et dérivés : Camptothécine, Désoxycytidine.
- effets indésirables : Camptothécine, Désoxycytidine, Fluorouracil, Leucovorine.
- mortalité : Carcinome du canal pancréatique, Tumeurs du pancréas.
- traitement médicamenteux : Carcinome du canal pancréatique, Tumeurs du pancréas.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Adulte d'âge moyen, Diarrhée, Estimation de Kaplan-Meier, Fatigue, Femelle, Humains, Liposomes, Mâle, Métastase tumorale, Neutropénie, Résultat thérapeutique, Sujet âgé, Vomissement.
English descriptors
- KwdEn :
- Aged, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Camptothecin (administration & dosage), Camptothecin (adverse effects), Camptothecin (analogs & derivatives), Carcinoma, Pancreatic Ductal (drug therapy), Carcinoma, Pancreatic Ductal (mortality), Deoxycytidine (administration & dosage), Deoxycytidine (adverse effects), Deoxycytidine (analogs & derivatives), Diarrhea (chemically induced), Fatigue (chemically induced), Female, Fluorouracil (administration & dosage), Fluorouracil (adverse effects), Humans, Kaplan-Meier Estimate, Leucovorin (administration & dosage), Leucovorin (adverse effects), Liposomes, Male, Middle Aged, Neoplasm Metastasis, Neutropenia (chemically induced), Pancreatic Neoplasms (drug therapy), Pancreatic Neoplasms (mortality), Treatment Outcome, Vomiting (chemically induced).
- MESH :
- chemical , administration & dosage : Camptothecin, Deoxycytidine, Fluorouracil, Leucovorin.
- chemical , adverse effects : Camptothecin, Deoxycytidine, Fluorouracil, Leucovorin.
- chemical , analogs & derivatives : Camptothecin, Deoxycytidine.
- chemically induced : Diarrhea, Fatigue, Neutropenia, Vomiting.
- drug therapy : Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms.
- mortality : Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Aged, Female, Humans, Kaplan-Meier Estimate, Liposomes, Male, Middle Aged, Neoplasm Metastasis, Treatment Outcome.
Abstract
Nanoliposomal irinotecan showed activity in a phase 2 study in patients with metastatic pancreatic ductal adenocarcinoma previously treated with gemcitabine-based therapies. We assessed the effect of nanoliposomal irinotecan alone or combined with fluorouracil and folinic acid in a phase 3 trial in this population.
DOI: 10.1016/S0140-6736(15)00986-1
PubMed: 26615328
Affiliations:
- Allemagne, Australie, Brésil, Corée du Sud, Espagne, France, Hongrie, Royaume-Uni, Taïwan, États-Unis
- Angleterre, Aquitaine, Arizona, Bavière, Catalogne, District de Haute-Bavière, Grand Londres, Grand Manchester, Hongrie centrale, Massachusetts, Missouri (État), Nevada, Nouvelle-Aquitaine, Rio Grande do Sul, Région capitale de Séoul
- Barcelone, Bordeaux, Budapest, Londres, Manchester, Munich, Porto Alegre, Saint-Louis (Missouri), Séoul
- École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lee, Kyung Hun" sort="Lee, Kyung Hun" uniqKey="Lee K" first="Kyung-Hun" last="Lee">Kyung-Hun Lee</name><affiliation wicri:level="3"><nlm:affiliation>Seoul National University Hospital, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cunningham, David" sort="Cunningham, David" uniqKey="Cunningham D" first="David" last="Cunningham">David Cunningham</name><affiliation wicri:level="3"><nlm:affiliation>The Royal Marsden Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Blanc, Jean F" sort="Blanc, Jean F" uniqKey="Blanc J" first="Jean F" last="Blanc">Jean F. Blanc</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint-André, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint-André, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Hubner, Richard A" sort="Hubner, Richard A" uniqKey="Hubner R" first="Richard A" last="Hubner">Richard A. Hubner</name><affiliation wicri:level="3"><nlm:affiliation>The Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Christie NHS Foundation Trust, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name><affiliation wicri:level="1"><nlm:affiliation>China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Schwartsmann, Gilberto" sort="Schwartsmann, Gilberto" uniqKey="Schwartsmann G" first="Gilberto" last="Schwartsmann">Gilberto Schwartsmann</name><affiliation wicri:level="3"><nlm:affiliation>Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Clínicas de Porto Alegre, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Siveke, Jens T" sort="Siveke, Jens T" uniqKey="Siveke J" first="Jens T" last="Siveke">Jens T. Siveke</name><affiliation wicri:level="3"><nlm:affiliation>Klinikum rechts der Isar der T U München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar der T U München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Braiteh, Fadi" sort="Braiteh, Fadi" uniqKey="Braiteh F" first="Fadi" last="Braiteh">Fadi Braiteh</name><affiliation wicri:level="2"><nlm:affiliation>Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Comprehensive Cancer Centers of Nevada, Las Vegas, NV</wicri:regionArea><placeName><region type="state">Nevada</region></placeName></affiliation></author><author><name sortKey="Moyo, Victor" sort="Moyo, Victor" uniqKey="Moyo V" first="Victor" last="Moyo">Victor Moyo</name><affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Belanger, Bruce" sort="Belanger, Bruce" uniqKey="Belanger B" first="Bruce" last="Belanger">Bruce Belanger</name><affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dhindsa, Navreet" sort="Dhindsa, Navreet" uniqKey="Dhindsa N" first="Navreet" last="Dhindsa">Navreet Dhindsa</name><affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bayever, Eliel" sort="Bayever, Eliel" uniqKey="Bayever E" first="Eliel" last="Bayever">Eliel Bayever</name><affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Von Hoff, Daniel D" sort="Von Hoff, Daniel D" uniqKey="Von Hoff D" first="Daniel D" last="Von Hoff">Daniel D. Von Hoff</name><affiliation wicri:level="2"><nlm:affiliation>TGen, Phoenix, and HonorHealth, Scottsdale, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>TGen, Phoenix, and HonorHealth, Scottsdale, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Chen, Li Tzong" sort="Chen, Li Tzong" uniqKey="Chen L" first="Li-Tzong" last="Chen">Li-Tzong Chen</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. Electronic address: leochen@nhri.org.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26615328</idno><idno type="pmid">26615328</idno><idno type="doi">10.1016/S0140-6736(15)00986-1</idno><idno type="wicri:Area/PubMed/Corpus">002263</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002263</idno><idno type="wicri:Area/PubMed/Curation">002237</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002237</idno><idno 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USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Li, Chung Pin" sort="Li, Chung Pin" uniqKey="Li C" first="Chung-Pin" last="Li">Chung-Pin Li</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Bodoky, Gyorgy" sort="Bodoky, Gyorgy" uniqKey="Bodoky G" first="György" last="Bodoky">György Bodoky</name><affiliation wicri:level="3"><nlm:affiliation>St László Teaching Hospital, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>St László Teaching Hospital, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Dean, Andrew" sort="Dean, Andrew" uniqKey="Dean A" first="Andrew" last="Dean">Andrew Dean</name><affiliation wicri:level="1"><nlm:affiliation>St John of God Hospital, Subiaco, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St John of God Hospital, Subiaco, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Shan, Yan Shen" sort="Shan, Yan Shen" uniqKey="Shan Y" first="Yan-Shen" last="Shan">Yan-Shen Shan</name><affiliation wicri:level="1"><nlm:affiliation>National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Cheng Kung University Hospital, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Jameson, Gayle" sort="Jameson, Gayle" uniqKey="Jameson G" first="Gayle" last="Jameson">Gayle Jameson</name><affiliation wicri:level="2"><nlm:affiliation>TGen, Phoenix, and HonorHealth, Scottsdale, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>TGen, Phoenix, and HonorHealth, Scottsdale, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Macarulla, Teresa" sort="Macarulla, Teresa" uniqKey="Macarulla T" first="Teresa" last="Macarulla">Teresa Macarulla</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital (HUVH) and Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital (HUVH) and Vall d'Hebron Institute of Oncology (VHIO), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lee, Kyung Hun" sort="Lee, Kyung Hun" uniqKey="Lee K" first="Kyung-Hun" last="Lee">Kyung-Hun Lee</name><affiliation wicri:level="3"><nlm:affiliation>Seoul National University Hospital, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cunningham, David" sort="Cunningham, David" uniqKey="Cunningham D" first="David" last="Cunningham">David Cunningham</name><affiliation wicri:level="3"><nlm:affiliation>The Royal Marsden Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Blanc, Jean F" sort="Blanc, Jean F" uniqKey="Blanc J" first="Jean F" last="Blanc">Jean F. Blanc</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint-André, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint-André, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Hubner, Richard A" sort="Hubner, Richard A" uniqKey="Hubner R" first="Richard A" last="Hubner">Richard A. Hubner</name><affiliation wicri:level="3"><nlm:affiliation>The Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Christie NHS Foundation Trust, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name><affiliation wicri:level="1"><nlm:affiliation>China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Schwartsmann, Gilberto" sort="Schwartsmann, Gilberto" uniqKey="Schwartsmann G" first="Gilberto" last="Schwartsmann">Gilberto Schwartsmann</name><affiliation wicri:level="3"><nlm:affiliation>Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Clínicas de Porto Alegre, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Siveke, Jens T" sort="Siveke, Jens T" uniqKey="Siveke J" first="Jens T" last="Siveke">Jens T. Siveke</name><affiliation wicri:level="3"><nlm:affiliation>Klinikum rechts der Isar der T U München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar der T U München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Braiteh, Fadi" sort="Braiteh, Fadi" uniqKey="Braiteh F" first="Fadi" last="Braiteh">Fadi Braiteh</name><affiliation wicri:level="2"><nlm:affiliation>Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Comprehensive Cancer Centers of Nevada, Las Vegas, NV</wicri:regionArea><placeName><region type="state">Nevada</region></placeName></affiliation></author><author><name sortKey="Moyo, Victor" sort="Moyo, Victor" uniqKey="Moyo V" first="Victor" last="Moyo">Victor Moyo</name><affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Belanger, Bruce" sort="Belanger, Bruce" uniqKey="Belanger B" first="Bruce" last="Belanger">Bruce Belanger</name><affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dhindsa, Navreet" sort="Dhindsa, Navreet" uniqKey="Dhindsa N" first="Navreet" last="Dhindsa">Navreet Dhindsa</name><affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bayever, Eliel" sort="Bayever, Eliel" uniqKey="Bayever E" first="Eliel" last="Bayever">Eliel Bayever</name><affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Von Hoff, Daniel D" sort="Von Hoff, Daniel D" uniqKey="Von Hoff D" first="Daniel D" last="Von Hoff">Daniel D. Von Hoff</name><affiliation wicri:level="2"><nlm:affiliation>TGen, Phoenix, and HonorHealth, Scottsdale, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>TGen, Phoenix, and HonorHealth, Scottsdale, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Chen, Li Tzong" sort="Chen, Li Tzong" uniqKey="Chen L" first="Li-Tzong" last="Chen">Li-Tzong Chen</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. Electronic address: leochen@nhri.org.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Camptothecin (administration & dosage)</term><term>Camptothecin (adverse effects)</term><term>Camptothecin (analogs & derivatives)</term><term>Carcinoma, Pancreatic Ductal (drug therapy)</term><term>Carcinoma, Pancreatic Ductal (mortality)</term><term>Deoxycytidine (administration & dosage)</term><term>Deoxycytidine (adverse effects)</term><term>Deoxycytidine (analogs & derivatives)</term><term>Diarrhea (chemically induced)</term><term>Fatigue (chemically induced)</term><term>Female</term><term>Fluorouracil (administration & dosage)</term><term>Fluorouracil (adverse effects)</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Leucovorin (administration & dosage)</term><term>Leucovorin (adverse effects)</term><term>Liposomes</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Metastasis</term><term>Neutropenia (chemically induced)</term><term>Pancreatic Neoplasms (drug therapy)</term><term>Pancreatic Neoplasms (mortality)</term><term>Treatment Outcome</term><term>Vomiting (chemically induced)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Camptothécine (administration et posologie)</term><term>Camptothécine (analogues et dérivés)</term><term>Camptothécine (effets indésirables)</term><term>Carcinome du canal pancréatique (mortalité)</term><term>Carcinome du canal pancréatique (traitement médicamenteux)</term><term>Diarrhée ()</term><term>Désoxycytidine (administration et posologie)</term><term>Désoxycytidine (analogues et dérivés)</term><term>Désoxycytidine (effets indésirables)</term><term>Estimation de Kaplan-Meier</term><term>Fatigue ()</term><term>Femelle</term><term>Fluorouracil (administration et posologie)</term><term>Fluorouracil (effets indésirables)</term><term>Humains</term><term>Leucovorine (administration et posologie)</term><term>Leucovorine (effets indésirables)</term><term>Liposomes</term><term>Mâle</term><term>Métastase tumorale</term><term>Neutropénie ()</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Tumeurs du pancréas (mortalité)</term><term>Tumeurs du pancréas (traitement médicamenteux)</term><term>Vomissement ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Camptothecin</term><term>Deoxycytidine</term><term>Fluorouracil</term><term>Leucovorin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Camptothecin</term><term>Deoxycytidine</term><term>Fluorouracil</term><term>Leucovorin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Camptothecin</term><term>Deoxycytidine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Camptothécine</term><term>Désoxycytidine</term><term>Fluorouracil</term><term>Leucovorine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Camptothécine</term><term>Désoxycytidine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Diarrhea</term><term>Fatigue</term><term>Neutropenia</term><term>Vomiting</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Pancreatic Ductal</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Camptothécine</term><term>Désoxycytidine</term><term>Fluorouracil</term><term>Leucovorine</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Carcinoma, Pancreatic Ductal</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Carcinome du canal pancréatique</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome du canal pancréatique</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Liposomes</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Metastasis</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Diarrhée</term><term>Estimation de Kaplan-Meier</term><term>Fatigue</term><term>Femelle</term><term>Humains</term><term>Liposomes</term><term>Mâle</term><term>Métastase tumorale</term><term>Neutropénie</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Vomissement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nanoliposomal irinotecan showed activity in a phase 2 study in patients with metastatic pancreatic ductal adenocarcinoma previously treated with gemcitabine-based therapies. We assessed the effect of nanoliposomal irinotecan alone or combined with fluorouracil and folinic acid in a phase 3 trial in this population.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>Corée du Sud</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Royaume-Uni</li><li>Taïwan</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Arizona</li><li>Bavière</li><li>Catalogne</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Grand Manchester</li><li>Hongrie centrale</li><li>Massachusetts</li><li>Missouri (État)</li><li>Nevada</li><li>Nouvelle-Aquitaine</li><li>Rio Grande do Sul</li><li>Région capitale de Séoul</li></region><settlement><li>Barcelone</li><li>Bordeaux</li><li>Budapest</li><li>Londres</li><li>Manchester</li><li>Munich</li><li>Porto Alegre</li><li>Saint-Louis (Missouri)</li><li>Séoul</li></settlement><orgName><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Wang Gillam, Andrea" sort="Wang Gillam, Andrea" uniqKey="Wang Gillam A" first="Andrea" last="Wang-Gillam">Andrea Wang-Gillam</name></region><name sortKey="Bayever, Eliel" sort="Bayever, Eliel" uniqKey="Bayever E" first="Eliel" last="Bayever">Eliel Bayever</name><name sortKey="Belanger, Bruce" sort="Belanger, Bruce" uniqKey="Belanger B" first="Bruce" last="Belanger">Bruce Belanger</name><name sortKey="Braiteh, Fadi" sort="Braiteh, Fadi" uniqKey="Braiteh F" first="Fadi" last="Braiteh">Fadi Braiteh</name><name sortKey="Dhindsa, Navreet" sort="Dhindsa, Navreet" uniqKey="Dhindsa N" first="Navreet" last="Dhindsa">Navreet Dhindsa</name><name sortKey="Jameson, Gayle" sort="Jameson, Gayle" uniqKey="Jameson G" first="Gayle" last="Jameson">Gayle Jameson</name><name sortKey="Moyo, Victor" sort="Moyo, Victor" uniqKey="Moyo V" first="Victor" last="Moyo">Victor Moyo</name><name sortKey="Von Hoff, Daniel D" sort="Von Hoff, Daniel D" uniqKey="Von Hoff D" first="Daniel D" last="Von Hoff">Daniel D. Von Hoff</name></country><country name="Taïwan"><noRegion><name sortKey="Li, Chung Pin" sort="Li, Chung Pin" uniqKey="Li C" first="Chung-Pin" last="Li">Chung-Pin Li</name></noRegion><name sortKey="Chen, Li Tzong" sort="Chen, Li Tzong" uniqKey="Chen L" first="Li-Tzong" last="Chen">Li-Tzong Chen</name><name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name><name sortKey="Shan, Yan Shen" sort="Shan, Yan Shen" uniqKey="Shan Y" first="Yan-Shen" last="Shan">Yan-Shen Shan</name></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Bodoky, Gyorgy" sort="Bodoky, Gyorgy" uniqKey="Bodoky G" first="György" last="Bodoky">György Bodoky</name></region></country><country name="Australie"><noRegion><name sortKey="Dean, Andrew" sort="Dean, Andrew" uniqKey="Dean A" first="Andrew" last="Dean">Andrew Dean</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Macarulla, Teresa" sort="Macarulla, Teresa" uniqKey="Macarulla T" first="Teresa" last="Macarulla">Teresa Macarulla</name></region></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Kyung Hun" sort="Lee, Kyung Hun" uniqKey="Lee K" first="Kyung-Hun" last="Lee">Kyung-Hun Lee</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cunningham, David" sort="Cunningham, David" uniqKey="Cunningham D" first="David" last="Cunningham">David Cunningham</name></region><name sortKey="Hubner, Richard A" sort="Hubner, Richard A" uniqKey="Hubner R" first="Richard A" last="Hubner">Richard A. Hubner</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Blanc, Jean F" sort="Blanc, Jean F" uniqKey="Blanc J" first="Jean F" last="Blanc">Jean F. Blanc</name></region></country><country name="Brésil"><region name="Rio Grande do Sul"><name sortKey="Schwartsmann, Gilberto" sort="Schwartsmann, Gilberto" uniqKey="Schwartsmann G" first="Gilberto" last="Schwartsmann">Gilberto Schwartsmann</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Siveke, Jens T" sort="Siveke, Jens T" uniqKey="Siveke J" first="Jens T" last="Siveke">Jens T. Siveke</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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